By employing SPE for sample preparation, the original sample matrix is transformed into a simpler environment. This simplification makes the sample more suitable for subsequent analytical chromatography, leading to improved qualitative and quantitative analysis. Additionally, the simplified sample matrix reduces the demands on the analytical system, which could potentially extend the system’s lifespan.

An optimal SPE procedure can offer several advantages, such as enabling the conversion of sample matrices to be more compatible with the target chromatographic method, concentrating analytes to enhance sensitivity, eliminating interferences that cause high background or misleading peaks during chromatographic analysis, safeguarding the analytical column from contaminants, and automating the extraction process.